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MEK5, Active

品牌
Sigma-Aldrich
货号
SRP0732
规格纯度
PRECISIO?Kinase, recombinant
价格
5467.45 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
MEK5, Active
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Useful for kinase assay and Western blot.

生化/生理作用

Recombinant full-length human MEK5 was expressed byBaculovirusin Sf9 insect cells using an N-terminal GST tag. MEK5 or MAP2K5 (mitogen-activated protein kinase kinase 5) is a dual specificity protein kinase that belongs to the MAP kinase kinase family which specifically interacts with and activates MAPK7/ERK5. MEK5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MEK5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation(1). The rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer (CRC)(2).

重悬

Formulated in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, with 25% glycerol.

储存及稳定性

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

半岛bd体育手机客户端 性质

重组 expressed in baculovirus infectedSf9 cells
测定 0.05-0.1 μg/μL
70-95% (SDS-PAGE)
形式 frozen liquid
specific activity 70-100 nmol/min·mg (radiometric)
分子量 ~77 kDa
登记号 BC008838
运输 dry ice
储存温度 ?70℃
Gene Information human ... MEK5(5607)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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