MAL-dPEG^?₈-TFP ester

半岛bd体育手机客户端 说明

特点和优势

MAL-dPEG^?₈-TFP ester is a heterobifunctional, linear crosslinking reagent containing a maleimide group on one end of the single molecular weight dPEG^?spacer arm and an amine-reactive active ester on the other end. The maleimide group reacts readily and specifically with free sulfhydryl groups in aqueous media at pH 6.5-7.5. The 2,3,5,6-tetrafluorophenyl (TFP) ester is used widely in reactions with primary amines. The TFP-amine reactions can be carried out in aqueous or organic solvent. The dPEG^?spacer is hydrophilic and non-immunogenic. Because it is a single molecular weight product, it gives the user precise spatial control. The dPEG^?spacer also improves water solubility, decreases immunogenicity, and increases the hydrodynamic volume of the conjugate. The increased hydrodynamic volume results in longer serum half-life in vivo.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

基本信息

经验(实验)分子式	C32H44F4N2O13
分子量	740.69
MDL编号	MFCD28505514
PubChem化学物质编号	329823941
NACRES	NA.22

半岛bd体育手机客户端 性质

测定	>90%
形式	solid or viscous liquid
reaction suitability	reagent type: cross-linking reagent reactivity: amine reactive reagent type: cross-linking reagent reactivity: thiol reactive
聚合物结构设计	shape: linear functionality: heterobifunctional
运输	ambient
储存温度	?20℃
SMILES string	O=C(OC1=C(F)C(F)=CC(F)=C1F)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN2C(C=CC2=O)=O)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable