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位置:首页 > 品牌 > Sigma-Aldrich > 溶葡球菌酶 来源于溶葡萄球菌

Lysostaphin from Staphylococcus staphylolyticus

溶葡球菌酶 来源于溶葡萄球菌

品牌
Sigma-Aldrich
CAS
9011-93-2
货号
SAE0091
规格纯度
free of DNA contaminants, suitable for Microbiome research, lyophilized powder, ≥500 units/mg protein
价格
2759 *本价格含增值税费
促销
服务
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  • 增值税票
数量
-+
半岛bd体育手机客户端 名称:
9011-93-2
Lysostaphin from Staphylococcus staphylolyticus
Glycyl-glycine Endopeptidase
溶葡球菌酶 来源于溶葡萄球菌
溶葡萄球菌酶
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Purified extracellular lysostaphin from S. staphylolyticus SAE0091 undergoes strict quality control testing to ensure the absence of detectable levels of contaminating DNA using 35 cycles PCR amplification of 16S and 18S rDNA using universal primer sets.
Lysostaphin is a zinc metalloenzyme isolated from a bacterial culture of Staphylococcus staphylolyticus. It has specific lytic action against other Staphylococcus species, including S. aureus.1,2 Lysostaphin has
hexosaminidase, amidase, and endopeptidase activities. It cleaves polyglycine crosslinks in the cellular wall which leads to cell lysis of Staphylococcus species, but not of other bacterial genera. [Pharmaceuticals 2010, 3(4), 1139-1161]
Lysostaphin is a single polypeptide chain of 246 amino acids, a molecular mass of 26,926 Da, isoelectric point of 9.5, (5) and an activity pH optimum of 7.5.(6)

生化/生理作用

Lysostaphin is a zinc endopeptidase with a molecular weight of approximately 25 kDa. Because lysostaphin cleaves the polyglycine cross-links in the peptidoglycan layer of the cell wall of Staphylococcus species it has been found useful for cell lysis and also as a potential anti-microbial therapeutic. pH Optimum for activity: ~7.5.
溶葡萄球菌素是一种分子量约为25 kDa的锌内肽酶。 由于溶葡萄球菌酶能裂解 葡萄球菌 类细胞壁肽聚糖层中的聚甘氨酸交联键,它已被发现可用于细胞裂解,并具有潜在的抗菌治疗作用。
活性最佳pH:~7.5

单位定义

One unit will reduce the turbidity (A620) of a suspension of Staphylococcus aureus cells from 0.250 to 0.125 in 10 min at pH 7.5 at 37℃ in a 6.0 ml reaction mixture.

外形

Supplied as a lyophilized powder containing 50–70% protein with the balance primarily as NaCl.

基本信息

酶学委员会(EC)编号3.4.24.75 ( BRENDA | IUBMB )
MDL编号MFCD00131556

半岛bd体育手机客户端 性质

生物来源fermentation/recombinant
形式lyophilized powder
specific activity≥500 units/mg protein
分子量 27 kDa
特点DNA free
运输wet ice
储存温度−20℃

安全信息

象形图GHS08
警示用语:Danger
危险声明H334
预防措施声明P261 - P284 - P304 + P340 + P312 - P501
危险分类Resp. Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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