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LXRα-ligand binding domain (215-667) human

品牌
Sigma-Aldrich
货号
SRP2042
规格纯度
recombinant, expressed inE. coli, ≥70% (SDS-PAGE)
价格
5156.64 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
LXRα-ligand binding domain (215-667) human
LXR-a
LXRA
RLD-1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Liver X receptors (LXRs) are nuclear receptors that regulate the metabolism of cholesterol and bile acids. There are two subtypes of LXRs, LXR α and LXR β. LXRa is preferentially expressed in liver, small intestine, kidney and spleen. In contrast, LXR β expression is ubiquitous. The genomic structure and the promoter regions of the two LXR genes contain specific regulatory sites, which suggest that LXRs may have physiological roles in the immune system. Like other nuclear receptors, LXRs heterodimerize with retinoid X receptor (RXR) for function. LXRs are activated by naturally occurring oxysterols and regulate the expression of target genes, including ATP binding cassette transporter 1 (ABC1), ATP binding cassette transporter 8 (ABC8) and cholesterol ester transfer protein (CETP). The ligand binding domain (LBD) of LXR determines ligand specificity and mediates the trans-activation function of the receptor.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥70% (SDS-PAGE)
形式 frozen liquid
分子量 ~30.6 kDa
包装 pkg of 10 μg
浓度 300 μg/mL
颜色 clear colorless
NCBI登记号 NM_005693
UniProt登记号 Q13133
运输 dry ice
储存温度 ?70℃
Gene Information human ... NR1H3(10062)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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