半岛bd体育手机客户端 说明
生化/生理作用
Lumiracoxib (COX189) is an orally active, potent and selective cyclooxygenase-2 inhibitor (Ki= 60 nM/COX-2 vs. 3.2 μM/COX-1) that inhibits COX-2-mediated PGE2 production in human whole blood (IC50= 130 nM; stimulation = 50 μM A23187), but not COX-1-dependent TxB2 production (IC50= 67 μM; stimulation = 10 μg/mL LPS). Lumiracoxib showsin vivoanti-inflammatory efficacy against carrageenan-induced paw oedema (ED30= 0.35 mg/kg p.o.), CFA-induced hyperalgesia (ED30= 5.1 mg/kg p.o.), as well as adjuvant-induced arthritis (ED50= 3 mg/kg/day p.o.) in ratsin vivo.
基本信息
经验(实验)分子式 | C15H13ClFNO2 |
分子量 | 293.72 |
MDL编号 | MFCD07186254 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | white to beige |
溶解性 | DMSO: 2 mg/mL, clear |
储存温度 | 2-8℃ |
SMILES string | ClC1=CC=CC(F)=C1NC2=CC=C(C)C=C2CC(O)=O |
安全信息
象形图 | |
警示用语: | Warning |
危险声明 | H302 |
预防措施声明 | P264 - P270 - P301 + P312 - P501 |
危险分类 | Acute Tox. 4 Oral |
储存分类代码 | 11 - Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |