半岛bd体育手机客户端 说明
生化/生理作用
Lobaplatin (D-19466) is a third-generation platinum anticancer agent in vitro and in vivo, consisting of ~50:50 mixture of the two trans-1,2-cyclobutanedimethanamine diastereomers in complex with L-lactic acid. Llobaplatin shows antitumor efficacy against various human cancer cancer xenografts and significantly prolongs the survival of mice bearing P388 leukemia (mean life span increase post single i.p. in mg/kg = 46%/4.64 & 77/14.7). Compared to first and second generation platinum compounds, lobaplatin appears to be more stable, less toxic, have a better therapeutic index and may overcome tumor resistance.
基本信息
| 经验(实验)分子式 | C9H18N2O3Pt |
| 分子量 | 397.33 |
半岛bd体育手机客户端 性质
| 质量水平 | 100 |
| 测定 | ≥98% (NMR) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | H2O: 2 mg/mL, clear (Warmed) |
| 储存温度 | ?20℃ |
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