Lipopolysaccharides fromProteus vulgaris

半岛bd体育手机客户端 说明

一般描述

Lipopolysaccharides (LPSs) are characteristic components of the cell wall of Gram-negative bacteria. LPS and its lipid A moiety stimulate cells of the innate immune system by the Toll-like receptor 4 (TLR4), a member of the Toll-like receptor protein family, which recognizes common pathogen-associated molecular-patterns (PAMPs).
Proteus vulgarisis a rod-shaped Gram-negative, facultative anaerobe bacterium. It inhabits the intestinal tract of humans and animals and can be found in soil, water and feces.P. vulgarisis a member of the Enterobacteriaceae family which are opportunistic pathogens in humans, responsible for urinary tract and burn infections.

Chemical structures of LPS fromProteus sp. are different from each other. These differences can be associated with the virulence and pathogenesis of the bacteria. It has been reported that the LPS chemical structure fromP. vulgariscan influence the crystallization of mineral urine components (such as calcium and magnesium), resulting in stone formation in the kidney.

应用

Antibodies produced in rickettsial infections were found to react with LPS fromProteus vulgarisandProteus mirabilis. This phenomenon allows the purified LPS from these two species to serve as a tool for diagnosis of rickettsiosis (scrub typhus, caused by the bacteriumOrientia sp.) in the Weil-Felix test.

半岛bd体育手机客户端 性质

安全信息