半岛bd体育手机客户端 说明
一般描述
LAG3 (lymphocyte activation gene 3) is an inhibitory CD4 (cluster of differentiation)-related molecule, and is expressed by activated CD4+and CD8+T cells.
生化/生理作用
LAG3 (lymphocyte activation gene 3) is a negative regulator of T-cell proliferation where it suppresses T-cell receptor (TCR)-mediated calcium fluxes and modulates the memory T-cell pool size. It is a CD4 (cluster of differentiation) homolog that functions as a ligand for MHC (major histocompatibility complex) II. Membrane expression of LAG3 modulates the suppressive function of Tregs (T-regulatory) bothin vivoandin vitro. HIV-1 (human immunodeficiency virus) infection results in significant increase in LAG3 peripheral blood and lymph node expression, which is exhibited on both CD4+and CD8+T cells, and this is linked with disease progression. In melanoma, this protein is responsible for TLR (Toll-like receptor)-independent activation of plasmacytoid dendritic cells (pDCs) at tumor sites, which is partially implicated in driving an immune-suppressive environment.
外形
Solution in PBS.
其他说明
The sequence coding for the 4 extracellular Ig-like domains of human LAG-3 (D1-D4) is fused to the Fc portion of human IgG1.
基本信息
| NACRES | NA.32 |
半岛bd体育手机客户端 性质
| 生物来源 | human |
| 重组 | expressed in CHO cells |
| 测定 | >99% (SDS-PAGE) |
| 形式 | liquid |
| 分子量 | ~80 kDa by SDS-PAGE |
| 包装 | pkg of 50 μg |
| 浓度 | ≥0.2 mg/mL |
| 杂质 | <0.1 EU/μg endotoxin, tested |
| 颜色 | clear |
| UniProt登记号 | P18627 |
| 运输 | wet ice |
| 储存温度 | ?20℃ |
| Gene Information | human ... LAG3(3902) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
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