半岛bd体育手机客户端 说明
包装
5, 25 mg in glass bottle
生化/生理作用
JNJ-40418677 is a γ-secretase modulator that selectively blocks γ-site cleavage of the APP without affecting processing of Notch. In human neuroblastoma cells and rat primary neuronal cultures, JNJ-40418677 blocked secretion of Aβb42 (IC50= 20 nM), with no affects on total Ab concentration, Notch signaling or COX activity.In vivoexperiments showed that JNJ-40418677 dose dependently inhibited Aβ42 accumulation in the brain while promoting an increase in Aβ38.
基本信息
经验(实验)分子式 | C26H22F6O2 |
分子量 | 480.44 |
NACRES | NA.77 |
半岛bd体育手机客户端 性质
质量水平 | 100 |
测定 | ≥98% (HPLC) |
形式 | powder |
颜色 | white to beige |
溶解性 | DMSO: 15 mg/mL, clear |
创始人 | Johnson & Johnson |
相关疾病 | Alzheimer′s disease |
储存温度 | 2-8℃ |
安全信息
象形图 | |
警示用语: | Danger |
危险声明 | H300 - H413 |
预防措施声明 | P264 - P270 - P273 - P301 + P310 - P405 - P501 |
危险分类 | Acute Tox. 2 Oral - Aquatic Chronic 4 |
储存分类代码 | 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich