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IL17R/CD217 human

品牌
Sigma-Aldrich
货号
SRP6435
规格纯度
recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE)
价格
3896.85 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
IL17R/CD217 human
CDw217
CANDF5
IL-17RA
IL17R
hIL-17R
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Interleukin 17 receptor A (IL17RA), also known as cluster of differentiation w217 (CDw217), is a pro-inflammatory cytokine secreted by activated T-lymphocytes. IL 17RA associates with IL 17RC to form a signaling receptor complex for IL17 and IL17F. Ligand and IL 17RA ligation promotes T cell activation and the production of IL - 6, G-CSF, SCF, and multiple pro-inflammatory chemokines. Defects in IL17RA are the cause of familial candidiasis type 5 (CANDF5).
The IL17RA (Interleukin 17 receptor A) gene is mapped to human chromosome 22q11.1 and is expressed ubiquitously and exhibits a broad tissue distribution.

生化/生理作用

Interleukin 17 receptor A (IL17RA) offers protection against pathogenic infection as it plays an important role in host defence mechanism. IL17RA deficiency might lead to the risk of chronic mucocutaneous candidiasis. IL-17A is a proinflammatory cytokine and its immune response is mediated by IL17RA.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in HEK 293 cells
标签 6-His tagged (C-terminus)
测定 ≥98% (SDS-PAGE)
形式 lyophilized
分子量 calculated mol wt 34.3 kDa
observed mol wt 55-60 kDa (DTT-reduced. Protein migrates due to glycosylation. Leu 33 is the predicted N-terminal.)
包装 pkg of 10 and 50 μg
UniProt登记号 Q96F46
运输 wet ice
储存温度 ?20℃
Gene Information human ... IL17RA(23765)

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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