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IL-28 human

品牌
Sigma-Aldrich
货号
SRP4978
规格纯度
recombinant, expressed inE. coli, ≥85% (SDS-PAGE), ≥85% (HPLC)
价格
4427.91 *本价格含增值税费
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半岛bd体育手机客户端 名称:
IL-28 human
IFN-λ 2
Interleukin-28A
IL28A
Cytokine ZCYTO20
Interferon-λ 2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

IL-28 (interleukin 28), or IFNL2 (interferon λ2), belongs to the novel IFN type III family, which contains IL-29 and IL-28A and IL-28B. IL-28A and IL-28B share >95% sequence identity. This gene is localized to human chromosome 19.
Recombinant human IL-28A produced inEscherichia coliis a single, non-glycosylated, polypeptide chain containing 175 amino acids and having a molecular mass of 19.6kDa.

生化/生理作用

IL-28A (interleukin 28) can inhibit multiple types of virus, and is also capable of preventing HSV-1 (herpes simplex virus type 1) infection of human neuronal cells. The antiviral property of IL-28A is attributable to IL-28A being capable of activating the expression of various Toll-like receptors (TLRs) and stimulating the TLR-mediated antiviral pathway, such as IFN regulatory factor 7, IFN-α, and the central IFN-α stimulated antiviral genes. IL-28A also acts as an inhibitory factor in HCV (hepatitis C virus) replication, and its expression is increased in HCV patients. This HCV antiviral activity is the result of IL-28A activating JAK-STAT (Janus kinase-signal transducer and activator of transcription) signaling pathway and the activation of certain interferon-stimulated genes (ISGs), such as 6-16 and 1-8U. Therefore, it might have potential as a therapeutic target in the treatment of HCV.

外形

Lyophilized without additives.

重悬

Reconstitute in sterile dH2O not less than 100 μg/ml. This solution can then be diluted into other aqueous buffers.
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

基本信息

MDL编号 MFCD06798670
NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥85% (HPLC)
≥85% (SDS-PAGE)
形式 lyophilized
分子量 ~19.6 kDa
包装 pkg of 20 μg
杂质 endotoxin, tested
NCBI登记号 Q8IZJ0
运输 wet ice
储存温度 ?20℃
Gene Information human ... IL28(282616)

Sigma-Aldrich

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