IL-2 R beta/CD122 human

半岛bd体育手机客户端 说明

一般描述

Interleukin-2 receptor (IL-2R)/ cluster of differentiation 122 (CD122) is a heterotrimeric protein, encoded by the gene mapped to human chromosome 22q12.3. The encoded protein is expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α subunit is involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. IL2R β is a member of the type I cytokine receptor family.

应用

Interleukin 2 receptor subunit β (IL2RB)/cluster of differentiation 122 (CD122) human has been used to study the effect of this cytokine on the expression of Klf15 in neurons.

生化/生理作用

Interleukin 2 receptor subunit β (IL2RB) is involved in signal transduction via its ligand interleukin-2. It is also implicated in inflammation. Cluster of differentiation 122 (CD122) is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed in HEK 293 cells
标签	6-His tagged (C-terminus)
测定	≥90% (SDS-PAGE)
形式	lyophilized
分子量	calculated mol wt 25.4 kDa observed mol wt 40 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 27 is the predicted N-terminus.)
包装	pkg of 10 μg
杂质	<1 EU/μg endotoxin (LAL test)
UniProt登记号	P14784
运输	wet ice
储存温度	?20℃
Gene Information	human ... IL2RB(3560)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable