HDAC6 H216A human

半岛bd体育手机客户端 说明

一般描述

HDAC6 (histone deacetylase 6) belongs to the HDAC family of proteins. HDACs are responsible for deacetylation of nuclear histone and nonhistone proteins, including transcription factors. The mutation H216A results in catalytically inactive HDAC6.
Human HDAC6 with H216A mutation (GenBank Accession No. NM_006044), full length with N-terminal GST tag, MW= 161kDa, expressed in a Baculovirus expression system.

生化/生理作用

HDAC6 (histone deacetylase 6) is involved in the control of microtubules, growth factor-mediated chemotaxis, stress response in presence of misfolded protein and tumor invasion. It also participates in EGF (epidermal growth factor)-mediated β-catenin nuclear presence and activation of c-myc. In mouse model, HDAC6 is implicated in oncogene-induced tumorigenesis. HDAC6 is the main deacetylase for α-tubulin and thus, is involved in cell motility. It is also involved in the formation of SGs (stress granules) and SG proteins. Mutations in the 3′-UTR of the HDAC6 gene suppresses hsa-miR-433-mediated post-transcriptional regulation. This results in overexpression of HDAC6, thereby causing X-linked chondrodysplasia.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed in baculovirus infectedSf9 cells
测定	≥75% (SDS-PAGE)
形式	aqueous solution
分子量	161 kDa
包装	pkg of 50 μg
储存条件	avoid repeated freeze/thaw cycles
浓度	0.65 mg/mL
NCBI登记号	NM_006044
UniProt登记号	Q9UBN7
运输	dry ice
储存温度	?70℃
Gene Information	human ... HDAC6(10013)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable