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HDAC-6 human

品牌
Sigma-Aldrich
货号
SRP0108
规格纯度
recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)
价格
8831.52 *本价格含增值税费
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半岛bd体育手机客户端 名称:
HDAC-6 human
HD6
JM21
histone deacetylase 6
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

HDAC6 (histone deacetylase 6) is a member of the HDAC family of enzyme which are generally linked with gene expression and chromatin dynamics. This protein resides exclusively in the cytoplasm and is present in the perinuclear punctate structures as well as the leading edges of the cell.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

HDAC6 (histone deacetylase 6) functions as a microtubule or tubulin deacetylase, which in turn regulates microtubule-dependent chemotactic cell motility. This protein shows colocalization with p150gluedprotein, a dynactin component. It contains a ubiquitin binding zinc finger, and interacts with ubiquitinated proteins post-proteasomal inhibition. It is essential for the survival of inflammatory breast cancers (IBCs), though does not function as an oncogene. Treatment of IBC cells with HDAC6 inhibitor ricolinostat (ACY1215) results in the inhibition of IBC cell proliferation bothin vitroandin vivo.

单位定义

One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37℃.

外形

Formulated in 40 mM Tris-HCl pH8.0, 110mM NaCl, 2.2 mM KCl, 0.04% Tween20, 3mM DTT, and 20% glycerol.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in baculovirus infected insect cells
测定 ≥80% (SDS-PAGE)
形式 aqueous solution
分子量 159 kDa
包装 pkg of 50 μg
NCBI登记号 BC069243
UniProt登记号 Q9UBN7
运输 dry ice
储存温度 ?70℃
Gene Information human ... HDAC6(10013)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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