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HCV-NS4A/NS3-1b Protease, Histag, strain HC-J4 from hepatitis C virus

品牌
Sigma-Aldrich
货号
SRP2151
规格纯度
recombinant, expressed inE. coli, ≥80% (SDS-PAGE)
价格
7018.5 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
HCV-NS4A/NS3-1b Protease, Histag, strain HC-J4 from hepatitis C virus
Hepatitis C virus NS3 protease
NS4ANS3 complex
NS3
pfam02907
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Persistent infection with hepatitis C virus (HCV) is a common cause of chronic liver disease, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. HCV is an enveloped, single-stranded RNA virus with a 9.6-kb positive-polarity genome, which encodes a polyprotein precursor of about 3,000 amino acids. The HCV polyprotein is proteolytically processed by cellular and HCV proteases into at least 10 distinct products. NS3 serine protease and helicase as well as NS5B RNA-dependent RNA polymerase are believed to be components of a replication complex responsible for viral RNA replication and have been shown to be essential for the HCV replication in chimpanzees. These HCV enzymes have been the major targets for the development of HCV-specific therapeutics during the past decade. The HCV NS3/4A protease is responsible for cleavage at four sites within the HCV polyprotein to generate the N termini of the NS4A, NS4B, NS5A, and NS5B proteins. It has been shown that the central region (amino acids 21-30) of the 54-residue NS4A protein is essential and sufficient for the enhancement of proteolytic activity of the NS3 serine protease. In recent phase I trials, a 2-3-log reduction of HCV viral load was observed after a 2-day treatment with a serine protease inhibitor, which provided the first proof-of-concept evidence that HCV NS3/4A protease inhibitors could be a new therapeutic option for hepatitis C patients.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 hepatitis C virus
重组 expressed inE. coli
测定 ≥80% (SDS-PAGE)
形式 frozen liquid
分子量 ~22.7 kDa
包装 pkg of 10 μg
浓度 500 μg/mL
颜色 colorless to clear
NCBI登记号 X61596
运输 dry ice
储存温度 ?70℃
Gene Information hepatitis C virus ... HCVgp1(951475)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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