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Glucose-6-phosphate Isomerase human

品牌
Sigma-Aldrich
货号
SAE0005
规格纯度
recombinant, expressed inE. coli
价格
5206.02 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
Glucose-6-phosphate Isomerase human
PGI
GPI
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Glucose-6-phosphate isomerase (GPI) is a homodimeric enzyme ubiquitously present in most organisms. GPI catalyzes the interconversion between glucose-6-phosphate and fructose-6-hosphate, the second step of the glycolytic pathway. In mammals, Glucose-6-phosphate isomerase also acts as an autocrine motility factor (AMF), a neuroleukin, and a maturation factor. GPI deficiency is the second most common erythroenzymopathy of glycolytic enzymes after pyruvate kinase deficiency. Inherited deficiency of the enzymatic activity of GPI causes hereditary nonspherocytic hemolytic anemia (HNSHA) in humans, a severe deficiency that can be associated with hydrops fetalis (a-thalassaemia), immediate neonatal death, and neurological impairment.

物理属性

C-terminal histidine-tagged

单位定义

One unit will convert 1.0 mmole of D -fructose 6-phosphate to D -glucose 6-phosphate per inute at pH 7.4 at 25 ℃.

外形

Supplied as a solution in 50 mM Tris-HCl pH 7.5, and 50% glycerol

基本信息

酶学委员会(EC)编号 5.3.1.9 ( BRENDA | IUBMB )
NACRES NA.54

半岛bd体育手机客户端 性质

质量水平 200
重组 expressed inE. coli
测定 ≥95% (SDS-PAGE)
specific activity ≥200 units/mg protein
储存温度 ?20℃

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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