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位置: 首页> 品牌> Sigma-Aldrich> gAcrp30/Adiponectin from mouse

gAcrp30/Adiponectin from mouse

品牌
Sigma-Aldrich
货号
SRP4592
规格纯度
recombinant, expressed inE. coli, ≥98% (SDS-PAGE)
价格
4186.79 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
gAcrp30/Adiponectin from mouse
Adipocyte-specific protein AdipoQ
Adipolean
apm-1
AdipoQ
Adiponectin
ACRP30
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Acrp30 (adipocyte complement-related protein), or cytokine adiponectin, is a hormone produced and secreted by differentiated adipocytes. This protein is composed of an N-terminal collagenous domain and a C-terminal globular trimerization domain. It exists in plasma predominantly as trimeric, hexameric or other high-molecular weight forms. The globular subunit gAcrp30 is however absent in plasma and is biologically active. gAcrp30 is the truncated form of full length of Acrp30, and functions as a ligand of AdipoR1.
Recombinant mouse gAcrp30 is a 16.6 kDa protein consisting of 145 amino acid residues.

生化/生理作用

In obese mice and humans, adiponectin/gAcrp30 (adipocyte complement-related protein) mRNA expression is reduced, therefore linking this hormone to energy homeostasis. In incubated mouse muscle and cultured cells, gAcrp30 leads to an increase in fatty acid oxidation. This hormone is also linked to anti-atherogenesis, and in apoE-deficient mice, overexpression of gAcrp30 results in significant attenuation of atherosclerosis. Long-term administration of this hormone in mice results in weight loss without reduction in food intake. This hormone is capable of reducing proliferation of MDA-ERα7 cell line. Studies show that ratio of gAcrp30 to leptin and the ERα (estrogen receptor) status of cells are key in determining BRCA (breast cancer) cell growth.

外形

Lyophilized from 5 mM Tris, pH 7.6.

重悬

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in 5 mM Tris, pH 7.6 to a concentration of 0.1-1.0 mg/mL. This stock solution can then be diluted into other aqueous buffers.

半岛bd体育手机客户端 性质

生物来源 mouse
重组 expressed inE. coli
测定 ≥98% (SDS-PAGE)
形式 lyophilized
分子量 ~16.6 kDa
包装 pkg of 25 μg
储存条件 avoid repeated freeze/thaw cycles
杂质 endotoxin, tested
NCBI登记号 Q60994
运输 wet ice
储存温度 ?20℃
Gene Information mouse ... Adipoq(11450)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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