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G9a human

品牌
Sigma-Aldrich
货号
SRP0135
规格纯度
recombinant, expressed inE. coli, ≥70% (SDS-PAGE)
价格
8831.52 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
G9a human
KMT1C
Lysine N-methyltransferase 1C
HLA-B-associated transcript 8
Euchromatic histone-lysine N-methyltransferase 2
EHMT2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Human G9a (euchromatic histone-lysineN-methyltransferase 2) with N-terminal GST tag, MW = 74.6 kDa, expressed in anE. coliexpression system. G9a is a member of SET (Su(var)3-9, enhancer-of-zeste and trithorax) domain containing, Su(var)3-9 family of proteins. This domain is evolutionary conserved.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

The encoded protein G9a (euchromatic histone-lysineN-methyltransferase 2) is a methyltransferase that methylates lysine residues of histone H3. Overexpression of G9a is observed in cancer. It is known to participate in cancer cell migration, invasion and metastasis. G9a is an epigenetic regulator and can inhibit the action of tumor suppressor genes, thereby, contributes to carcinogenesis. Thus, G9a is considered to be an oncogenic and metastatic factor. It also affects DNA damage repair mechanism, which might make tumor cells resistant to radiation and chemotherapy. G9a serves as a target for cancer therapy including breast cancer.

单位定义

One unit is defined as the amount of enzyme required to methylate 1 pmol of substrate/min at 37℃.

外形

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.

制备说明

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70℃. Note: Enzyme is very sensitive to freeze/thaw cycles.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥70% (SDS-PAGE)
形式 aqueous solution
分子量 74.6 kDa
包装 pkg of 50 μg
浓度 >0.02 mg/mL
NCBI登记号 NM_006709
UniProt登记号 Q96KQ7
运输 dry ice
储存温度 ?70℃
Gene Information human ... EHMT2(10919)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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