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G3335

品牌
Sigma-Aldrich
CAS
36099-95-3
货号
SML1449
规格纯度
≥98% (HPLC)
价格
1396.09 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
36099-95-3
G3335
L-Tryptophyl-L-glutamic acid
H-Trp-Glu-OH
WE
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

包装

50, 250 mg in glass bottle

生化/生理作用

G3335 ( L-tryptophyl-L-glutamic acid) is a cell-permeable dipeptide that acts as a selective and reversible PPARγ antagonist with a Kd value of 8.34 μM for PPARγ and much lower activity at other PPAR subtypes. G3335 reversibly and competitively blocks activation of PPARγ by the PPARγ agonist rosiglitazone, and conversely, in rat astrocyte culture higher levels of rosiglitazone reduced harmful effects induced by G3335. At higher concentration G3335 may act as a PPARα agonist, interacting with the PPARα ligand binding domain with a KD of 120 μM. G3335 is reported to reduce hepatic lipid accumulation in lipid-loaded hepatocytes by activation of PPARα.

基本信息

经验(实验)分子式 C16H19N3O5
分子量 333.34
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to off-white
储存温度 ?20℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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