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FXR (Farnesoid-X-activated receptor) human

品牌
Sigma-Aldrich
货号
SRP2039
规格纯度
recombinant, expressed inE. coli, ≥80% (SDS-PAGE)
价格
5416.19 *本价格含增值税费
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数量
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半岛bd体育手机客户端 名称:
FXR (Farnesoid-X-activated receptor) human
NR1H4
FXR
Farnesol receptor HRR-1
retinoid receptor
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

It is part of the superfamily of nuclear receptors. FXR is expressed in the liver and ileum. The gene encoding this protein is localized on human chromosome 12q23.1.

生化/生理作用

Farnesoid-X-activated receptor (FXR) was originally identified and cloned in rat as an orphan nuclear hormone receptor based on hybridization with a degenerate oligonucleotide designed from the highly conserved nuclear hormone receptor DNA binding domain. FXR functions as a heterodimer with RXR and binds to sequence elements in the promoters of target genes. The FXR/RXR heterodimer binds with highest affinity to inverted repeats separated by 1 bp (IR-1) and with low affinity to direct repeats separated by 4 and 5 bp (DR-4 and DR-5). As is the case for other nuclear hormone receptors, FXR regulates target gene activity in response to ligand. While initial studies suggested that farnesol and retinoid metabolites were likely ligands for FXR, current data support the notion that FXR is a bile acid sensor that plays an integral role in bile acid synthesis and transport. In the small intestine, FXR regulates bile acid uptake through the upregulation of the ileal bile acid binding protein gene via binding to an upstream response element. The FXR/RXR heterodimer can be activated by the bile salt chenodeoxycholic acid (CDCA) and FXR is required for the bile salt-dependent transcriptional control of the human ABCB11 gene (the bile salt export pump). In addition, FXR has been shown to inhibit the cholesterol 7-hydrolase gene (CYP7A1) transcription.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥80% (SDS-PAGE)
形式 frozen liquid
分子量 ~56.6 kDa
包装 pkg of 10 μg
颜色 clear to colorless
NCBI登记号 U68233
UniProt登记号 Q96RI1
运输 dry ice
储存温度 ?70℃
Gene Information human ... HRR-1(9971)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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