FOLR2 human

半岛bd体育手机客户端 说明

一般描述

Folate receptor β, also known as Folate receptor 2, FBP, FOLR2, β-HFR, FBP/PL-1, FR-β, FR-P3, and is a member of the folate receptor (FOLR) family which mediates delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. The FOLR2 protein was originally thought to exist only in placenta, but is also detected in spleen, bone marrow, and thymus. FOLR2 is predominantly expressed in placenta, cells of the neutrophilic lineage, and some CD34+ hematopoietic progenitor cells. It is upregulated on myeloid leukemias, head and neck squamous cell carcinomas, and several nonepithelial cancers. It is also upregulated on macrophages and monocytes at chronic inflammatory sites including rheumatoid arthritis synovium and glioblastoma. FOLR2 is a marker for macrophages generated in the presence of M-CSF, but not GM-CSF. Its expression correlates with increased folate uptake ability. Folate conjugates of therapeutic drugs are a potential immunotherapy tool to target tumor-associated macrophages.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed in HEK 293 cells
标签	6-His tagged (C-terminus)
测定	≥95% (SDS-PAGE)
形式	lyophilized
分子量	calculated mol wt 26 kDa observed mol wt 30-33 kDa by SDS-PAGE (DTT-reduced. Thr17 is the predicted N-terminal.)
包装	pkg of 10 and 50 μg
杂质	<1 EU/μg endotoxin (LAL test)
UniProt登记号	P14207
运输	wet ice
储存温度	?20℃
Gene Information	human ... FOLR2(2350)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable