Fc gamma RIIIB/CD16b human

半岛bd体育手机客户端 说明

一般描述

Cluster of differentiation 16 (CD16) is a low affinity type 1 transmembrane Fc receptor. It possesses two Ig-like extracellular domains. Cd16 has been identified as two isoforms, Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner. CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. CD16B also known as FCGR3B and FCG3B, is expressed specifically by polymorphonuclear leukocytes (neutrophils) and stimulated eosinophils.

生化/生理作用

Cluster of differentiation 16B (CD16B) or Fcγ RIIIB (FcγRIIIb) is the low affinity receptor for the Fc region of immunoglobulin γ. It binds complexed or aggregated IgG and also to monomeric IgG. Contrary to CD16A, CD16B is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. CD16B may serve as a trap for immune complexes in the peripheral circulation, which does not activate neutrophils.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed in HEK 293 cells
标签	6-His tagged (C-terminus)
测定	≥98% (SDS-PAGE)
形式	lyophilized
分子量	calculated mol wt 21.7 kDa observed mol wt 38-50 kDa (DTT-reduced. Protein migrates due to glycosylation. Gly 17 is the predicted N-terminal.)
包装	pkg of 10 and 50 μg
杂质	<1 EU/μg endotoxin (LAL test)
UniProt登记号	O75015
运输	wet ice
储存温度	?20℃
Gene Information	human ... FCGR3B(2215)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable