ErbB4/HER4 human

半岛bd体育手机客户端 说明

一般描述

Receptor tyrosine-protein kinase erbB-4 (ErbB4), also known as Her4, is a single-pass type I transmembrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF) family of growth factors. ErbB4 is expressed in normal skeletal muscle, heart, pituitary, brain and several breast carcinomas. ERBB4 contains multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphatidylinositol-3 kinase binding site and a PDZ domain binding motif. The gene encoding this protein is localized on human chromosome 2q34.

生化/生理作用

Receptor tyrosine-protein kinase erbB-4 (ErbB4) binds to and is activated by neuregulins-2 and -3, heparin-binding EGF-like growth factor and β-cellulin. Ligand binding induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. ErbB4 appears to play important roles in neuronal development, development of the heart and cancer. Mutations in this gene have been associated with cancer. Other single-nucleotide polymorphisms and a risk haplotype have been linked to schizophrenia.

外形

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

重悬

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8℃ for up to 1 month. For extended storage, it is recommended to store at -20℃.

基本信息

NACRES

NA.32

半岛bd体育手机客户端 性质

生物来源	human
重组	expressed in HEK 293 cells
标签	6-His tagged (C-terminus)
测定	≥95% (SDS-PAGE)
形式	lyophilized
分子量	calculated mol wt 70.6 kDa observed mol wt 95-110 kDa by SDS-PAGE (reducing) (Glu26 is the predicted N-terminal .)
包装	pkg of 10 and 50 μg
杂质	<1 EU/μg endotoxin (LAL test)
UniProt登记号	Q15303
运输	wet ice
储存温度	?20℃
Gene Information	human ... ErbB4(2066)

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable