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位置: 首页> 品牌> Sigma-Aldrich> 3′-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid

Eltrombopag

(Z)-3′-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylic acid

品牌
Sigma-Aldrich
CAS
496775-61-2
货号
SML3182
规格纯度
价格
780.67 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
496775-61-2
Eltrombopag
(Z)-3′-(2-(1-(3,4-Dimethylphenyl)-3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)hydrazinyl)-2′-hydroxybiphenyl-3-carboxylic acid
SB-497115
SB 497115
3′-[(2Z)-2-[1-(3,4-Dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazinyl]-2′-hydroxy[1,1′-biphenyl]-3-carboxylic acid
SB497115
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Eltrombopag is an orally active nonpeptide thrombopoietin receptor (TpoR) agonist that selectively induces STAT activation and proliferation (EC50 = 270 & 30 nM, respectively) of hToR-transfected, but not non-transfected, BAF3 cells. Eltrombopag increases the differentiation of primary human CD34(+) bone marrow cells into CD41(+) megakaryocytesex vivo(EC50 = 100 nM) and exhibits thrombopoietic activity in chimpanzeesin vivo(10 mg/kg/day p.o.).

基本信息

经验(实验)分子式 C25H22N4O4
分子量 442.47
MDL编号 MFCD20926253

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 faint yellow to dark orange
溶解性 DMSO: 2 mg/mL, clear
储存温度 2-8℃
SMILES string OC1=C(C=CC=C1N/N=C2C(C)=NN(C/2=O)C3=CC(C)=C(C=C3)C)C4=CC=CC(C(O)=O)=C4

安全信息

象形图 GHS05GHS07GHS08GHS09
警示用语: Danger
危险声明 H302 - H318 - H373 - H411
预防措施声明 P260 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P314
危险分类 Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - STOT RE 2
储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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