dPEG^?₁₂-SATA (S-acetyl-dPEG^?₁₂-NHS ester)

半岛bd体育手机客户端 说明

特点和优势

dPEG^?₁₂-SATA (S-acetyl-dPEG^?₁₂-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG^?linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG^?₁₂-SATA to install a protected thiol connected to the molecule via the dPEG^?linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG^?linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG^?-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.

法律信息

Products Protected under U.S. Patents # 7,888,536 B2
dPEG is a registered trademark of Quanta BioDesign

基本信息

经验(实验)分子式	C33H59NO17S
分子量	773.88
MDL编号	MFCD21363255
PubChem化学物质编号	329823963
NACRES	NA.22

半岛bd体育手机客户端 性质

测定	>90%
形式	solid or viscous liquid
reaction suitability	reagent type: chemical modification reagent reactivity: amine reactive reagent type: cross-linking reagent
聚合物结构设计	shape: linear functionality: monofunctional
运输	ambient
储存温度	?20℃
SMILES string	O=C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCSC(C)=O)ON1C(CCC1=O)=O

安全信息

储存分类代码	13 - Non Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable