DO34 - 半岛电竞官方网址

DO34

品牌

Sigma-Aldrich

CAS

1848233-58-8

货号

SML2732

包装型号

规格纯度

≥98% (HPLC)

价格

1045.52 元 *本价格含增值税费

促销

数量

- +

半岛bd体育手机客户端名称：

1848233-58-8
DO34
3-(Phenylmethyl)-4-[[4-[4-(trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl]carbonyl]-1-piperazinecarboxylic acid, 1,1-dimethylethyl ester
(2-Benzyl-4-{[(2-methyl-2-propanyl)oxy]carbonyl}piperazinyl){4-[(4-trifluoromethoxy)phenyl]-1H-1,2,3-triazol-1-yl}methanone

半岛bd体育手机客户端介绍：

半岛bd体育手机客户端说明

生化/生理作用

DO34 is a brain-penetrant, selective and highly potent diacylglycerol lipase inhibitor (recom human DAGLα/β pIC₅₀= 8.2/8.1 by SAG hydrolysis; mouse brain DAGLα/β pIC₅₀= 9.1-9.3/8.6 by ABPP ReDiMe) with detectable off-target activity toward only ABHD6 & PLA2G7 among all mouse brain serine hydrolases and little affinity toward cannabinoid receptors CB1/2. DO34 blocks depolarization-induced suppression of excitation (DSE IC₅₀= 0.18 μM) and inhibition (100% DSI blockage at 1 μM) in mouse cerebellar and hippocampal slicesex vivo, and attenuate LPS-induced neuroinflammatory responses by lowering brain 2-AG & PGE2 level in micein vivo(50 mg/kg, i.p).

基本信息

经验(实验)分子式	C₂₆H₂₈F₃N₅O₄
分子量	531.53
MDL编号	MFCD31807614

半岛bd体育手机客户端性质

质量水平	100
测定	≥98% (HPLC)
形式	powder
颜色	white to beige
溶解性	DMSO: 2 mg/mL, clear
储存温度	?20℃
SMILES string	O=C(N1CCN(CC1CC2=CC=CC=C2)C(OC(C)(C)C)=O)N3N=NC(C4=CC=C(C=C4)OC(F)(F)F)=C3

安全信息

储存分类代码	11 - Combustible Solids
WGK	WGK 3
闪点(F)	Not applicable
闪点(C)	Not applicable