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位置: 首页> 品牌> Sigma-Aldrich> Dapagliflozin propanediol monohydrate

Dapagliflozin propanediol monohydrate

品牌
Sigma-Aldrich
CAS
960404-48-2
货号
SML2758
规格纯度
≥98% (HPLC)
价格
679.82 *本价格含增值税费
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半岛bd体育手机客户端 名称:
960404-48-2
Dapagliflozin propanediol monohydrate
Dapagliflozin propanediol hydrate
(1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-D-glucitol (S)-propane-1,2-diol (1:1) monohydrate
BMS 512148 propanediol hydrate
Dapagliflozin (S)-propylene glycol monohydrate
(2S,3R,4R,5S,6R)-2-(3-(4-Ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyl-tetrahydro-2H-pyran-3,4,5-triol propanediol monohydrate
BMS-512148 propanediol hydrate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

Dapagliflozin (BMS-512148) is an orally active, potent and selective renal sodium-dependent glucose cotransporter 2 (SGLT2; SLC5A2) inhibitor (human/rat SGLT2 IC50= 1.1/3 nM vs. human/rat SGLT1 IC50= 1.39/0.6 μM; R-methyl-D-glucopyranoside (AMG) uptake assay with respective CHO transfectants). Dapagliflozin reduces blood glucose levels (by 55% in streptozotocin (STZ)-induced hyperglycemic rats 5 hrs post 0.1 mg/kg p.o.) by preventing the renal glucose reabsorption process and promoting glucose excretion in urine with good pharmacokinetic properties and oral availability (84% in rats and 83% in dogs, respectively, post 1 mg/kg and 6.6 mg/kg p.o.)in vivo.

基本信息

经验(实验)分子式 C21H25ClO6·C3H8O2·H2O
分子量 502.98
MDL编号 MFCD28167768

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
旋光性 [α]/D 20 to 26, c = 0.2 in chloroform-d
储存条件 desiccated
颜色 white to beige
溶解性 DMSO: 2 mg/mL, clear
储存温度 ?20℃

安全信息

储存分类代码 11 - Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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