COX-2 Inhibitor screening kit

半岛bd体育手机客户端 说明

一般描述

Cyclooxygenase (COX), also known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for the formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. COX is the central enzyme in the biosynthetic pathway to prostanoids from arachidonic acid. There are two known isoenzymes: COX-1 and COX-2. COX-1 is constitutively expressed in many tissues and is the predominant form in gastric mucosa and in kidney. COX-2 is not expressed under normal conditions in most cells, but elevated levels are found during inflammation. Pharmacological inhibition of COX by non-steroidal anti-inflammatory drugs (NSAID) can provide relief from the symptoms of inflammation and pain.

特点和优势

COX-2 Inhibitor Screening Kit:

• Compatible with high-throughput handling systems.

适用性

The kit is suitable for screening, studying and characterizing COX-2 inhibitors.

原理

The assay is based on the fluorometric detection of Prostaglandin G2, the intermediate product generated by the COX enzyme.

半岛bd体育手机客户端 性质

质量水平	100
web metadata keyword.default	COX-2 Inhibitor Screening Kit|sigma-aldrich
detection method	fluorometric
储存温度	?20℃

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 3