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CK1 γ 2, active, GST tagged human

品牌
Sigma-Aldrich
货号
SRP5016
规格纯度
PRECISIO?Kinase, recombinant, expressed in baculovirus infectedSf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
价格
6468.88 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
CK1 γ 2, active, GST tagged human
CK1g2
CSNK1G2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Casein kinase 1 γ 2 (CK1γ2) is a member of the CK1 family of serine/threonine protein kinases which play an important role in diverse cell processes, including DNA replication and repair. It is a ubiquitously expressed cytoplasmic kinase. The gene encoding this protein is localized on human chromosome 19p13.3.

生化/生理作用

Casein kinase 1 γ 2 (CK1γ2) can interact and phosphorylate the metastatic tumor antigen 1 short form (MTA1s) co-localizing it in the cytoplasm. Phosphorylated MTA1s then sequesters the estrogen receptor-α in the cytoplasm of breast cancer cells. CK1γ2 hyperphosphorylates the ceramide transfer protein CERT leading to a decrease inde novosphingomyelin synthesis. The reduction in synthesis of sphingomyelin is reversed by the expression of CERT mutants that are not hyperphosphorylated.

外形

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

制备说明

after opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

重组 expressed in baculovirus infectedSf9 cells
半岛bd体育手机客户端 线 PRECISIO?Kinase
测定 ≥70% (SDS-PAGE)
形式 buffered aqueous glycerol solution
specific activity 25-35 nmol/min·mg
分子量 ~73 kDa
NCBI登记号 NM_001319
运输 dry ice
储存温度 ?70℃
Gene Information human ... CSNK1G2(1455)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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