半岛bd体育手机客户端 说明
生化/生理作用
Originally isolated fromAspergillus candidusLink, Chlorflavonin is a non-cytotoxic (up to 100 μM; MRC-5 and THP-1) antibiotic with antifungal activity against certain species of mold fungi (MIC = 0.08 μg/mL againstA. amstelodami, A. fumigalus, A. ochraceous; Paecilomyces variotiiMIC = 2.5 μg/mL,Botrytis cinereaMIC = 5 μg/mL). Chlorflavonin also exhibits antibiotic activity againstM. tuberculosis(MIC90 = 1.56 μM) by targeting acetohydroxyacid synthase (AHAS) catalytic subunit ilvB1. Chlorflavonin is superior to streptomycin againstM. tuberculosisinside infected macrophages, synergizes with isoniazid and delamanid, leading to a complete sterilization in liquid cultures.
基本信息
| 经验(实验)分子式 | C18H15ClO7 |
| 分子量 | 378.76 |
半岛bd体育手机客户端 性质
| 测定 | ≥98% (HPLC) |
| 形式 | powder |
| 颜色 | white to beige |
| 溶解性 | DMSO: 2 mg/mL, clear |
| 储存温度 | 2-8℃ |
| SMILES string | OC1=CC(OC)=C(C2=C1C(C(OC)=C(C3=C(O)C(Cl)=CC=C3)O2)=O)OC |
| InChI | 1S/C18H15ClO7/c1-23-11-7-10(20)12-14(22)18(25-3)15(26-17(12)16(11)24-2)8-5-4-6-9(19)13(8)21/h4-7,20-21H,1-3H3 |
| InChI key | JLSQXYITDXJTKL-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
Sigma-Aldrich
m.cnreagent.com
