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CHIRALPAK?CBH HPLC Column

CHIRAL-CBH 高效液相色谱柱

货号
58550AST
规格纯度
5 μm particle size, L × I.D. 10 cm × 4 mm
价格
38555.4 *本价格含增值税费
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半岛bd体育手机客户端 名称:
CHIRALPAK ?CBH HPLC Column
CHIRAL-CBH 高效液相色谱柱
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Hermansson described the use of natural proteins immobilized onto a silica support for chiral separations in 1983 (1). Proteins contain a large number of chiral centers of one configuration, and many other sites that contribute to the general retention process. Used primarily for the separation enantiomers of basic compounds, CHIRALPAK CBH phase has cellobiohydrolase as the chiral selector immobilized on spherical 5 μm silica particles. Used in reversed-phase mode, retention and enantioselectivity is regulated by changes of pH, buffer concentration and organic modifier. The mobile phases are mixtures of phosphate or acetate buffers and organic solvents such as 2-propanol or acetonitrile. The column is preferably used for the separation of enantiomers of basic drugs, particularly compounds containing one or more nitrogen atoms along with one or more hydrogen-bonding groups (alcohol, phenol, carbonyl, amide, ether, ester, etc.).

Features:

  • Direct reversed phase resolution of chiral molecules
  • Stable with a variety of organic modifiers
  • Available in analytical and semi-preparative sizes

(1) Hermansson, J. Direct liquid chromatographic resolution of racemic drugs using a1-acid glycoprotein as the chiral stationary phase. J. Chromatogr. A, 1983, 269, 71-80.

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法律信息

CHIRALPAK is a registered trademark of Daicel Corp.

基本信息

eCl@ss 32110501
NACRES SB.52

半岛bd体育手机客户端 性质

物料 stainless steel column
质量水平 100
半岛bd体育手机客户端 线 CHIRALPAK?
包装 pkg of 1 ea
manufacturer/tradename CHIRALPAK?
参数 137 bar pressure (2000 psi)
20-30 ℃ temperature
40 ℃ max. temp.
technique(s) HPLC: suitable
长度 × 内径 10 cm × 4 mm
基质 fully porous particle
基质活性基团 cellobiohydrolase phase
粒径 5 μm
operating pH 2-8
分离技术 chiral

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