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CDK4/Cyclin D1 active human

CDK4/活性人细胞周期蛋白 D1

品牌
Sigma-Aldrich
货号
SRP0373
规格纯度
recombinant, expressed in baculovirus infectedSf9 cells, ≥90% (SDS-PAGE)
价格
7031.79 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
CDK4/Cyclin D1 active human
CDK4/活性人细胞周期蛋白 D1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Cyclin D1 (CCND1) is a proto-oncogene. It is one of the three D-type cyclins. The gene encoding it is localized on human chromosome 11q13. Cyclin dependent kinase-like 4 (CDKL4) is part of the cyclin-dependent protein kinase (CDK) family. The gene encoding it is localized on human chromosome 12q14-15.
Recombinant, full length human CDK4 (Genbank Accession No. NM_000075), amino acids 16-271, with C-terminal His-tag and modifications (amino acids 43G-47G were replaced with EE, and T172A), MW=34 kDa, and human Cyclin D1 (Genbank accession number NM_053056), MW 29 kDa, were co-expressed in a Baculovirus-infected Sf9 cells expression system.

生化/生理作用

Cyclin D1 (CCND1) regulates the Wnt signaling pathway. It also regulates the progression of the cell cycle from the G1 to S phase in many cell types. CCND1 phosphorylates and inactivates retinoblastoma (Rb) protein. Cyclin D1 has been associated with mantle cell lymphoma. This protein is overexpressed in multiple cancers like hepatocellular carcinoma. Cyclin dependent kinase-like 4 (CDKL4) has been associated with various tumors and colorectal cancer. The protein regulates apoptosis of nucleated cells by modifying transcriptional regulation of genes governing cell proliferation and cell death. Like CCND1, it also modulates the progression of cycle from G1 to S phase.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in baculovirus infectedSf9 cells
测定 ≥90% (SDS-PAGE)
形式 aqueous solution
分子量 29 kDa (Cyclin D1)
34 kDa (CDK4)
包装 pkg of 20 μg
NCBI登记号 NM_000075 (CDK4)
NM_053056 (cyclin D1)
运输 dry ice
储存温度 ?70℃
Gene Information human ... CCND1(595), CDK4(1019)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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