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CD5 human

品牌
Sigma-Aldrich
货号
SRP6331
规格纯度
recombinant, expressed inE. coli, ≥80% (SDS-PAGE)
价格
5434.06 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
CD5 human
T1
LEU1
T-cell surface glycoprotein CD5
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

CD5 (cluster of differentiation 5) is a lymphocyte surface receptor. It is expressed by all T cells and the B1a subset of mature B cells (participating in the generation of low-affinity polyreactive antibodies). The CD5 gene is mapped to human chromosome 11q12.
Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed inEscherichia coli.

生化/生理作用

CD5 (cluster of differentiation 5) is required for fine tuning of TCR (T-cell receptor) signaling. It also controls activation-mediated T cell death and recognizes pathogen-associated molecular patterns. In T and B1 cells, CD5 negatively regulates the signaling by clonotypic antigen-specific receptor. CD5 is present in patients with rheumatoid arthritis, systemic lupus erythematosus, Sj?gren syndrome, Grave′s Basedow thyroiditis and type 1 diabetes mellitus. In infants, high levels of CD5+cells suggest the risk of development of allergic disease. The gene is also associated with peripheral T-cell lymphoma and mature B-cell neoplasms (mainly chronic lymphocytic leukemia and mantle cell lymphoma).

外形

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.4 M Urea and 10% glycerol.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥80% (SDS-PAGE)
形式 liquid
分子量 41 kDa (371 aa, 25-372 aa + His tag)
包装 pkg of 50 μg
浓度 1 mg/mL
杂质 <1 EU/μg endotoxin (LAL test)
UniProt登记号 P06127
运输 dry ice
储存温度 ?70℃
Gene Information human ... CD5(921)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

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