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CD274 from mouse

品牌
Sigma-Aldrich
货号
SRP6327
规格纯度
recombinant, expressed inE. coli, ≥85% (SDS-PAGE)
价格
5893.01 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
CD274 from mouse
B7H1
PDL1
A530045L16Rik
CD274 antigen
PDCD1L1
PDCD1LG1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Programmed cell death 1 ligand 1 (PD-L1), which is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules. PD-L1 is a cell surface immunoglobulin with two Ig-like domains within the extracellular region and a short cytoplasmic domain. The protein is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. Recombinant mouse CD274 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

生化/生理作用

Programmed cell death 1 ligand 1 (PD-L1) is involved in the regulation of cellular and humoral immune responses. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after lipopolysaccharide (LPS) and interferon-γ (IFNG) activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 is involved in the co-stimulatory signal, essential for T-cell proliferation and production of interleukin-10 (IL10) and IFNG, in an interleukin-2-dependent and a programmed cell death 1 (PDCD1)-independent manner.

外形

1 mg/mL in 20 mM Tris-HCl buffer (pH 8.0) containing 0.15 M NaCl and 10% glycerol.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 mouse
重组 expressed inE. coli
测定 ≥85% (SDS-PAGE)
形式 liquid
分子量 27.6 kDa (246 aa, 19-239 aa + His tag)
包装 pkg of 100 μg
浓度 1 mg/mL
杂质 <1 EU/μg endotoxin (LAL test)
UniProt登记号 Q9EP73
运输 dry ice
储存温度 ?70℃
Gene Information mouse ... CD274(60533)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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