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BTK (C481S), Active

品牌
Sigma-Aldrich
货号
SRP0708
规格纯度
PRECISIO?Kinase, recombinant
价格
5177.2 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
BTK (C481S), Active
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

应用

Useful for kinase assay and Western blot.

生化/生理作用

Recombinant full-length human BTK (C481S) was expressed byBaculovirusin Sf9 insect cells using an N-terminal His tag. BTK (also known as Bruton tyrosine kinase) plays a crucial role in B-lymphocyte differentiation and activation. BTK interacts with SRC homology 3 domains of FYN, LYN and HCK that are activated upon stimulation of B- and T-cell receptors(1).Defects in the BTK gene cause Agammaglobulinemia, an X-linked immunodeficiency characterized by failure to produce mature B lymphocyte cells and associated with a failure of Ig heavy chain rearrangement. The unique role of BTK makes it a desirable target for potential anti-cancer, anti-inflammatory and anti-viral agents as well as other treatments(2).

重悬

Formulated in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, with 25% glycerol.

储存及稳定性

Store in aliquots at -70℃. Avoid freeze/thaw cycles.

法律信息

PRECISIO is a registered trademark of sigma-aldrich Co. LLC

半岛bd体育手机客户端 性质

重组 expressed in baculovirus infectedSf9 cells
测定 70-95% (SDS-PAGE)
形式 frozen liquid
specific activity 40-56 nmol/min·mg (radiometric)
分子量 ~75 kDa
浓度 0.1 μg/μL
登记号 NM_005228
运输 dry ice
储存温度 ?70℃

安全信息

象形图 GHS07GHS08
警示用语: Danger
危险声明 H315 - H319 - H360D
预防措施声明 P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类 Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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