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BRD4 (49-170) GST tag human

品牌
Sigma-Aldrich
货号
SRP0459
规格纯度
recombinant, expressed inE. coli, ≥82% (SDS-PAGE)
价格
8831.52 *本价格含增值税费
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半岛bd体育手机客户端 名称:
BRD4 (49-170) GST tag human
HUNKI
CAP
Bromodomain containing 4
HUNK1
MCAP
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

BRD4 (bromodomain-containing protein 4) belongs to the BET (bromodomain and extra-terminal) family. The protein has two bromodomains (BD1 and BD2) connected via a long interdomain linker.
Human Bromodomain containing 4, also known as BRD4, HUNK1, or MCAP (GenBank Accession No. NM_058243) amino-acids 49-170 with N-terminal GST-tag, MW = 41.4kDa, expressed in anEscherichia coliexpression system.

生化/生理作用

BRD4 (bromodomain-containing protein 4) works as a reader of epigenetic marks and is involved in chromatin remodeling and transcriptional regulation. Therefore, it is a target for oncology, inflammation and cardiovascular disease. This gene is upregulated in hepatocellular carcinoma and is associated with poor prognosis. BRD4 is also associated with melanoma, hepatocellular carcinoma, multiple myeloma, Burkitt′s lymphoma, acute myeloid leukemia and breast cancer. BRD4 connects cell cycle and transcription, works as a scaffold for transcription factors and bookmarks active genes during mitosis. It interacts with acetylated histone-3 and histone-4 tails and helps in maintaining chromatin architecture. Also, it regulates transcription elongation via phosphorylation of RNA polymerase II.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥82% (SDS-PAGE)
形式 aqueous solution
分子量 41.4 kDa
包装 pkg of 100 μg
NCBI登记号 NM_058243
UniProt登记号 O60885
运输 dry ice
储存温度 ?70℃
Gene Information human ... BRD4(23476)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 2
闪点(F) Not applicable
闪点(C) Not applicable

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