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BRD3 (1-416) his tag human

品牌
Sigma-Aldrich
货号
SRP6413
规格纯度
recombinant, expressed inE. coli, ≥85% (SDS-PAGE)
价格
5893.01 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
BRD3 (1-416) his tag human
RING3L
Bromodomain containing protein 3
ORFX
RING3-like protein
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. The BET family of proteins, defined by tandem Bromodomains and an Extra Terminal domain, include BRD2, BRD3, BRD4, and BRDT. The BET proteins play a key role in many cellular processes, including inflammatory gene expression, mitosis, and viral/host interactions. The isolated individual or tandem bromodomains of BRD3 have been shown to bind acetylated histone tails, serving to couple histone acetylation marks to the transcriptional regulation of target promoters. Small molecule inhibitors of these interactions hold promise as useful therapeutics for human disease. Recombinant human BRD3 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

外形

0.5 mg/mL in Phosphate buffer saline (pH 7.4) containing 10% glycerol.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥85% (SDS-PAGE)
形式 liquid
分子量 48.1 kDa (439 aa, 1- 416 aa + His Tag)
包装 pkg of 100 μg
浓度 0.5 mg/mL
NCBI登记号 NM_007371
UniProt登记号 Q15059
运输 dry ice
储存温度 ?70℃
Gene Information human ... BRD3(8019)

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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