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BQCA

品牌
Sigma-Aldrich
CAS
338747-41-4
货号
SML0497
规格纯度
≥98% (HPLC)
价格
1225.94 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
338747-41-4
BQCA
1-(4-methoxybenzyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Benzyl quinolone carboxylic acid
半岛bd体育手机客户端 介绍:

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包装

10, 50 mg in glass bottle

生化/生理作用

BQCA is a potent muscarinic M1 receptor positive allosteric modulator with selectivity for M1 over M2-M5. It potentiates M1 activity in in vitro and in vivo assays and is orally bioavailable. Muscarinic 1 (M1) receptors are expressed in brain regions responsible for attention and memory, including hippocampus, cortex, and striatum. BQCA binds allosterically to M1 to enhance the binding and efficacy of ACh at the receptor. M1 activation is a proposed mechanism for increasing information processing in disease states, such as Alzheimer′s. M1 agonists are being studied as potential therapeutic agents to treat Alzheimer′s disease and the cognitive and negative symptoms of schizophrenia. BQCA has been shown to improve performance in cognition tasks and increase cerebral blood flow.

特点和优势

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

基本信息

经验(实验)分子式 C18H15NO4
分子量 309.32
MDL编号 MFCD01315710
PubChem化学物质编号 329825446
NACRES NA.77

半岛bd体育手机客户端 性质

质量水平 100
测定 ≥98% (HPLC)
形式 powder
颜色 white to beige
溶解性 DMSO: 10 mg/mL (clear solution)
储存温度 2-8℃
SMILES string COc1ccc(CN2C=C(C(O)=O)C(=O)c3ccccc23)cc1
InChI 1S/C18H15NO4/c1-23-13-8-6-12(7-9-13)10-19-11-15(18(21)22)17(20)14-4-2-3-5-16(14)19/h2-9,11H,10H2,1H3,(H,21,22)
InChI key BZBBTGCKPRSPGF-UHFFFAOYSA-N

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H302
危险分类 Acute Tox. 4 Oral
储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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