半岛bd体育手机客户端 说明
生化/生理作用
BIO 1211 is a selective, tight-binding α4β1 (VLA-4, very late antigen-4; koff = 1.4 x 10-4/s, KD = 70 pM) integrin antagonist (VCAM-Ig Jurkat surface binding IC50 = 1 nM; integrin-mediated cell adhesion IC50 = 4 nM/α4β1, 2 μM/α4β7, >100 μM/α1β1, α5β1, α6β1, αLβ2, αIIBβ3) based on the Leu-Asp-Val (LDV) sequence from the alternatively spliced connecting segment-1 (CS-1) of fibronectin (aa 1980-1983). In addition to probing α4β1-mediated cellular responses, BIO 1211 is also widely used in animal disease modelsin vivo, including MS (5-10 mg/kg; murine EAE) and asthma (1-10 mg/kg via intranasal or nebulizer to mice, rats, sheep; 3 mg/sheep iv.).
基本信息
经验(实验)分子式 | C36H48N6O9· xC2HF3O2 |
分子量 | 708.80 (free base basis) |
MDL编号 | MFCD02259692 |
半岛bd体育手机客户端 性质
测定 | ≥97% (HPLC) |
形式 | film lyophilized powder |
储存条件 | desiccated |
颜色 | white to beige |
运输 | wet ice |
储存温度 | ?20℃ |
安全信息
储存分类代码 | 13 - Non Combustible Solids |
WGK | WGK 3 |
闪点(F) | Not applicable |
闪点(C) | Not applicable |
Sigma-Aldrich