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位置: 首页> 品牌> Sigma-Aldrich> N-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-proline trifluoroacetate

BIO 1211 trifluoroacetate salt

品牌
Sigma-Aldrich
CAS
187735-94-0
货号
SML2497
包装型号
规格纯度
≥97% (HPLC)
价格
1642.3 *本价格含增值税费
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半岛bd体育手机客户端 名称:
187735-94-0
BIO 1211 trifluoroacetate salt
N-[2-[4-[[[(2-Methylphenyl)amino]carbonyl]amino]phenyl]acetyl]-L-leucyl-L-α-aspartyl-L-valyl-L-proline trifluoroacetate
N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-Leu-Asp-Val-Pro trifluoroacetate
BIO1211 trifluoroacetate
2-MPUPA-LDVP trifluoroacetate
N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-LDVP trifluoroacetate
4-(N′-(2-Methylphenyl)urea)-phenylacetyl-LDVP trifluoroacetate
N-[[4-[[[(2-Methylphenyl)amino]carbonyl]amino]-phenyl]acetyl]-fibronectin CS-1 fragment (1980-1983) trifluoroacetate
BIO-1211 trifluoroacetate
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

生化/生理作用

BIO 1211 is a selective, tight-binding α4β1 (VLA-4, very late antigen-4; koff = 1.4 x 10-4/s, KD = 70 pM) integrin antagonist (VCAM-Ig Jurkat surface binding IC50 = 1 nM; integrin-mediated cell adhesion IC50 = 4 nM/α4β1, 2 μM/α4β7, >100 μM/α1β1, α5β1, α6β1, αLβ2, αIIBβ3) based on the Leu-Asp-Val (LDV) sequence from the alternatively spliced connecting segment-1 (CS-1) of fibronectin (aa 1980-1983). In addition to probing α4β1-mediated cellular responses, BIO 1211 is also widely used in animal disease modelsin vivo, including MS (5-10 mg/kg; murine EAE) and asthma (1-10 mg/kg via intranasal or nebulizer to mice, rats, sheep; 3 mg/sheep iv.).

基本信息

经验(实验)分子式 C36H48N6O9· xC2HF3O2
分子量 708.80 (free base basis)
MDL编号 MFCD02259692

半岛bd体育手机客户端 性质

测定 ≥97% (HPLC)
形式 film
lyophilized powder
储存条件 desiccated
颜色 white to beige
运输 wet ice
储存温度 ?20℃

安全信息

储存分类代码 13 - Non Combustible Solids
WGK WGK 3
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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