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BCL2, GST tagged human

品牌
Sigma-Aldrich
货号
SRP5340
规格纯度
recombinant, expressed inE. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
价格
4588.16 *本价格含增值税费
促销
服务
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  • 增值税票
数量
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半岛bd体育手机客户端 名称:
BCL2, GST tagged human
Bcl-2
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

BCL2 gene encodes an integral inner mitochondrial membrane protein that acts as an antiapoptotic protein. The protein BAD can antagonize both the cell cycle and antiapoptotic functions of BCL2 through binding to the BH3 domain. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. BCL2 is phosphorylated on specific serine/threonine residues within the unstructured loop in response to diverse stimuli and such phosphorylation has been associated with the loss of the biological function of BCL2.
It is a target gene of nuclear factor κB (NF-κB). The gene encoding this protein is localized on human chromosome 18q21. B-cell lymphoma 2 (BCL-2) inhibits apoptosis in cells and has been shown to be upregulated in adenomas.

外形

Supplied in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.

制备说明

After opening, aliquot into smaller quantities and store at -70 ℃. Avoid repeating handling and multiple freeze/thaw cycles.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥70% (SDS-PAGE)
形式 buffered aqueous glycerol solution
分子量 ~51 kDa
NCBI登记号 NM_000633
application(s) cell analysis
运输 dry ice
储存温度 ?70℃
Gene Information human ... BCL2(596)

安全信息

储存分类代码 10 - Combustible liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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