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B7-1 (CD80), FC Fusion, Biotin Labeled

品牌
Sigma-Aldrich
货号
SRP0526
规格纯度
recombinant, expressed in HEK 293 cells
价格
8235.96 *本价格含增值税费
促销
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数量
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半岛bd体育手机客户端 名称:
B7-1 (CD80), FC Fusion, Biotin Labeled
CTLA-4 Counter-Receptor B7.1
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

CD80 or B7-1 is expressed in the antigen-presenting cells (APC). The CD80 gene is mapped to human chromosome 3q13.33.
Human secreted B7-1-Fc fusion protein, also known as CD80, with C-terminal Avitag?. GenBank Accession No. NM_005191, a.a 35-242 expressed in a HEK293 cell expression system and enzymatically biotin-labeled using Avitag?technology. MW = 52.5 kDa (monomer). This protein runs at a higher M.W. by SDS-PAGE due to glycosylation.

生化/生理作用

CD80 is an efficient costimulatory molecule essential for immune surveillance during carcinogenesis. It inhibits cancer progression. It regulates the T cell activation to control immune response. Cell stress increases the CD80 expression. Reduced expression of CD80 is observed in colon carcinoma. High levels of CD80 stimulate anti-tumor immune responses. Therefore, enhancing CD80 expression in tumors might serve as a potent approach for cancer immunotherapy. Urinary CD80 is recognized as an important biomarker for idiopathic nephrotic syndrome (INS). CD80 might be involved in proteinuria, actin reorganization, and podocyte migration. Its expression in podocytes is associated with minimal change disease (MCD).

外形

Aqueous solution

法律信息

AviTag is a trademark of Avidity, LLC

基本信息

NACRES NA.26

半岛bd体育手机客户端 性质

重组 expressed in HEK 293 cells
形式 frozen liquid
分子量 52.5 kDa
UniProt登记号 P33681
运输 dry ice
储存温度 ?70℃
Gene Information human ... CD8O(941)

安全信息

象形图 GHS07
警示用语: Warning
危险声明 H315 - H319
预防措施声明 P305 + P351 + P338
危险分类 Eye Irrit. 2 - Skin Irrit. 2
储存分类代码 12 - Non Combustible Liquids
WGK WGK 1

Sigma-Aldrich

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