半岛bd体育手机客户端 说明

应用

β₂-Microglobulin from human urine was used to test humoral CSF parameters in the differential diagnosis of hematologic CNS neoplasia. It was also used in the identification of CTL epitopes in hepatitis C virus by a genome-wide computational scanning and a rational design of peptide vaccine.

生化/生理作用

β₂microglobulin (β₂-M) is a polypeptide that associates with the heavy chain of class I major histocompatibility complex (MHC) antigens on the cell surface. The interaction is dynamic and plays a critical role in the stability of the MHC antigens and their ability to present peptide antigens in CD8⁺cells. A transient complex of MHC heavy chain and β₂-M is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-β₂-M complex to the cell surface. Absence of binding leads to degradation in the proteasome.

制备说明

Prepared by the method of Berggard and Bearn.

基本信息

MDL编号

MFCD00130615

半岛bd体育手机客户端 性质

测定	≥98% (SDS-PAGE)
形式	solution
UniProt登记号	P61769
储存温度	?20℃
Gene Information	human ... B2M(567)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable