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Aurora Kinase A active human

品牌
Sigma-Aldrich
CAS
458560-40-2
货号
SRP0354
规格纯度
recombinant, expressed in baculovirus infectedSf9 cells, ≥90% (SDS-PAGE)
价格
6973 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
458560-40-2
Aurora Kinase A active human
BTAK
AURA
ARK1
STK6
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

AURA/AURKA (aurora kinase A) is mapped to human chromosome 20q13.2. It is also termed as STK15 (serine/threonine kinase 15). This gene codes for a protein of 403 amino acids with regulatory and catalytic domains. AURA is overexpressed in several malignancies like invasive carcinomas of ovary, head, neck and breast.
Human Aurora kinase A (GenBank Accession No. NM_003600), amino acids 2- 403 with N-terminal HIS6-tag, MW=50 kDa, expressed in a Baculovirus infected Sf9 cell expression system.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

AURA/AURKA (aurora kinase A) modulates cell cycle checkpoints and plays important roles in centrosome division, cytoskeleton and cytokinesis. It sustains the integrity of chromosomes after DNA damage. The catalytic domain of AURKA possesses a serine/threonine kinase activity.

单位定义

One unit is defined as the amount of enzyme that will phosphorylate 1 pmol of Ser/Thr 1 peptide substarte per minute at pH 7.4 and 30℃.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed in baculovirus infectedSf9 cells
测定 ≥90% (SDS-PAGE)
形式 aqueous solution
分子量 50 kDa
包装 pkg of 10 μg
technique(s) activity assay: suitable
inhibition assay: suitable
NCBI登记号 NM_003600
UniProt登记号 O14965
运输 dry ice
储存温度 ?70℃
Gene Information human ... AURKA(6790)

安全信息

储存分类代码 12 - Non Combustible Liquids
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

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