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Ataxin3 active human

品牌
Sigma-Aldrich
货号
SRP0445
规格纯度
recombinant, expressed inE. coli, ≥59% (SDS-PAGE)
价格
6984.77 *本价格含增值税费
促销
服务
  • 原厂保证
  • 包邮
  • 增值税票
数量
- +
半岛bd体育手机客户端 名称:
Ataxin3 active human
ATX3
MJD
AT3
JOS
SCA3
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Ataxin3 (ATXN3) is encoded by the gene mapped to human chromosome 14q32. The encoded protein is characterized with a ubiquitin interaction motif (UIM) domain involved in binding mono and/or polyubiquitylated proteins.

应用

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

生化/生理作用

Ataxin3 (ATXN3) is a polyglutamine neurodegenerative disease protein involved in the ubiquitin-proteasome pathway. ATXN3 performs all the functions same as ubiquitin proteases such as, reducing polyubiquitylation of 125I-lysozyme by removing ubiquitin from polyubiquitin chains, cleaving a ubiquitin protease substrate and binding the specific ubiquitin protease inhibitor, ubiquitin-aldehyde. Mutation in the gene has been observed in spinocerebellar ataxia type 3 patients.

基本信息

NACRES NA.32

半岛bd体育手机客户端 性质

生物来源 human
重组 expressed inE. coli
测定 ≥59% (SDS-PAGE)
形式 aqueous solution
分子量 42 kDa
包装 pkg of 250 μg
NCBI登记号 NM_004993
UniProt登记号 P54252
运输 dry ice
储存温度 ?70℃
Gene Information human ... ATXN3(4287)

安全信息

象形图 GHS07GHS08
警示用语: Danger
危险声明 H315 - H319 - H360D
预防措施声明 P202 - P264 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类 Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
储存分类代码 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK WGK 1
闪点(F) Not applicable
闪点(C) Not applicable

Sigma-Aldrich

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