Apoptolidin A Ready Made Solution

半岛bd体育手机客户端 说明

一般描述

Chemical structure: macrolide

生化/生理作用

Apoptolidin A is a 20-membered macrolide shown to be selectively cytotoxic against several cancer cell lines and noncytotoxic against normal cells. The molecule was originally produced byNocardiopsisspecies, and its target site was identified as mitochondrial F₀F₁-ATPase.
Apoptolidin induces apoptosis selectively in rat glia cells transformed with the adenovirus oncogene E₁A. Several minor apoptolidin congeners were isolated, known as Apoptolidins A-D. All apoptolidins were reported to inhibit growth of H292 cancer cells (lung carcinoma) in the submicromolar range. Recently, a stereo-selective synthesis of the Apoptolidin disaccharide was reported.

基本信息

经验(实验)分子式	C58H96O21
分子量	1129.37
EC 号	200-664-3
PubChem化学物质编号	329825615

半岛bd体育手机客户端 性质

质量水平	200
生物来源	Amycolatopsissp.
形式	DMSO solution
浓度	1 mg/mL in DMSO
作用机制	enzyme | inhibits
抗生素抗菌谱	fungi
运输	dry ice
储存温度	?20℃
SMILES string	CC(/C=C1\C)=C\C(C)=C\[C@@H](C)[C@H](O[C@H]2[C@@H](O)[C@H](O)[C@@H](OC)[C@H](C)O2)/C=C/C(C)=C/CC[C@H](O)[C@@H](OC)CC([C@H]([C@]3([C@H](C)[C@@H](O)[C@@H](C)C(C[C@H](COC)O[C@H]4C[C@@](O)(C)[C@@H](O[C@H]5C[C@@H](OC)[C@H](O)[C@H](C)O5)[C@H](C)O4)O3)O)O)OC1=O
InChI	1S/C58H96O21/c1-29-17-16-18-40(59)43(69-13)25-45(76-55(65)33(5)23-31(3)21-30(2)22-32(4)41(20-19-29)77-56-51(63)50(62)52(71-15)37(9)74-56)53(64)58(67)35(7)48(60)34(6)42(79-58)24-39(28-68-12)75-47-27-57(11,66)54(38(10)73-47)78-46-26-44(70-14)49(61)36(8)72-46/h17,19-23,32,34-54,56,59-64,66-67H,16,18,24-28H2,1-15H3/b20-19+,29-17+,30-22+,31-21+,33-23+/t32-,34+,35-,36+,37+,38+,39-,40+,41-,42?,43+,44-,45?,46+,47+,48+,49-,50+,51+,52+,53-,54+,56+,57+,58-/m1/s1
InChI key	WILMROCKORZEMQ-XIQAQMKHSA-N

安全信息

储存分类代码	10 - Combustible liquids
WGK	WGK 2
闪点(F)	188.6 °F
闪点(C)	87 ℃