Anti-ZNF175 antibody produced in rabbit

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一般描述

ZNF175 (zinc finger protein 175) is composed of 13 adjacent C2H2 type zinc finger motifs and a Krüppel-associated box (KRAB) domain essential for transcriptional suppression. It is localized in the cytosol and nucleus.

免疫原

Zinc finger protein 175 recombinant protein epitope signature tag (PrEST)

应用

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project (www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.

生化/生理作用

ZNF175 (zinc finger protein 175) has an ability to supress the Tat-induced viral LTR (long terminal repeat) promoter activity during HIV (human immunodeficiency virus)-1 replication. It suppresses the cellular response of several chemokine receptors. Upregulated expression of the protein has been reported in U937 cells which directly plays an important role in neurotrophin production and neuronal survival. It exhibits an antiretroviral property which has an impact on the accumulation of processing products, in the cytoplasm of perivascular brain macrophages, in advanced HIV encephalitis cases.

特点和优势

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

联系

Corresponding Antigen APREST83427.

外形

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

法律信息

Prestige Antibodies is a registered trademark of sigma-aldrich Co. LLC

基本信息

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