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Anti-ZNF746 antibody produced in rabbit

品牌
Sigma-Aldrich
货号
SAB4200530
规格纯度
~1.0 mg/mL, affinity isolated antibody
价格
5045.46 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-ZNF746 antibody produced in rabbit
Anti-Parkin-interacting Substrate, PARIS
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

Zinc finger protein 746, also known as PARIS, parkin interacting substrate (ZNF746 ) is a 644 amino acid protein. It has a Kruppel-associated box (KRAB) at its N-terminal and a C2HC/C2H2 type zinc finger at its C terminals. This protein is highly conserved among human, mouse and rat, and widely expressed in many tissues.

免疫原

synthetic peptide corresponding to an internal sequence of human ZNF746, conjugated to KLH. The corresponding sequence is identical in human ZNF746 isoform 2, and in mouse and rat ZNF746.

应用

Anti-ZNF746 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生化/生理作用

Zinc finger protein 746, also known as PARIS, parkin interacting substrate (ZNF746 ) accumulates in Parkinson′s disease (PD) models and in human PD brain. Hence it play a role in the progress of PD disease. ZNF746 is also regulated by the E3 ubiquitin ligase, parkin. In addition, overexpression of ZNF746 leads to the selective loss of dopaminergic neurons in the substantia nigra.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
质量水平 200
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~90 kDa
species reactivity rat, human, mouse
增强验证 recombinant expression
Learn more aboutAntibody Enhanced Validation
浓度 ~1.0 mg/mL
technique(s) indirect immunofluorescence: 2.5-5.0 μg/mL using SH-SY-5Y cells.
western blot: 1.0-2.0 μg/mL using using rat brain extracts (S2 fraction) and NIH3T3 fibroblast cell extracts.
UniProt登记号 Q6NUN9
运输 dry ice
储存温度 ?20℃
Gene Information human ... ZNF746(155061)
mouse ... Zfp746(69228)
rat ... Zfp746(312303)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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