Anti-Yes-associated protein (YAP1) Antibody, clone 4D11.1

半岛bd体育手机客户端 说明

一般描述

The YAP1 gene encodes a protein that binds to the SH3 (Src homology 3) domain of the Yes proto-oncogene product. As a transcriptional regulator, it can act as a coactivator and a corepressor, and serves as a critical downstream regulatory target in the Hippo signaling pathway. Additionally, it plays a critical role in regulating organ size and in tumor suppression by restricting proliferation and promoting apoptosis. The human YAP1 gene is well conserved among higher eukaryotes, but may not be conseved in yeast. Yes-associated protein expression is almost ubiquitous in adult human tissues, but is not detectable in peripheral blood leukocytes.

免疫原

GST-tagged recombinant protein corresponding to human Yes-associated protein (YAP1).

应用

Research Sub Category
Cell Cycle, DNA Replication & Repair
Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected Yes-associated protein (YAP1) in HeLa and A431 cells.
Research Category
Epigenetics & Nuclear Function
Anti-Yes-associated protein (YAP1) Antibody, clone 4D11.1 detects level of Yes-associated protein (YAP1) & has been published & validated for use in WB & IC.

质量

Evaluated by Western Blot in HeLa cell lysate.

Western Blot Analysis: 0.5 ?g/mL of this antibody detected Yes-associated protein (YAP1) in 10 ?g of HeLa cell lysate.

目标描述

~65 kDa observed

外形

Purified mouse monoclonal IgG1κ supernatant containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Format: Purified
Protein G Purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

分析说明

Control
Hela cell lysate

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

eCl@ss	32160702
NACRES	NA.41

半岛bd体育手机客户端 性质

质量水平	100
生物来源	mouse
抗体形式	purified immunoglobulin
antibody product type	primary antibodies
克隆	4D11.1, monoclonal
species reactivity	human
technique(s)	immunocytochemistry: suitable western blot: suitable
同位素/亚型	IgG1κ
NCBI登记号	NP_001123617
UniProt登记号	P46937
运输	wet ice
Gene Information	human ... YAP1(10413)

安全信息

储存分类代码	12 - Non Combustible Liquids
WGK	WGK 1
闪点(F)	Not applicable
闪点(C)	Not applicable