Anti-XTP3-B antibody produced in rabbit

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一般描述

XTP3-transactivated gene B precursor (XTP3-B), also known as Erlectin is an ER-resident lectin. XTP3-B contains two mannose 6-phosphate receptor homology (MRH) domains in its sequence. The XTP3-B gene is mapped to human chromosome 2p16.2.

应用

Anti-XTP3-B antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

生化/生理作用

XTP3-transactivated gene B precursor (XTP3-B), plays a role in endoplasmic-reticulum-associated protein degradation (ERAD) selection and targeting processes. Human XTP3-B associates with the SEL1L/HRD1 ubiquitin ligase complex in the ER membrane and with the ER chaperone BiP, forming an ER quality control scaffold complex. This large complex is involved in identifying and sorting of misfolded glycoproteins and non-glycosylated proteins prior to retrotranslocation into the cytoplasm for degradation.

外形

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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