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位置: 首页> 品牌> Sigma-Aldrich> Anti-5′-3′ exoribonuclease 1

Anti-XRN1 antibody produced in rabbit

Anti-5′-3′ exoribonuclease 1

品牌
Sigma-Aldrich
货号
SAB4200028
规格纯度
~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
价格
4618.16 *本价格含增值税费
促销
服务
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数量
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半岛bd体育手机客户端 名称:
Anti-XRN1 antibody produced in rabbit
Anti-DKFZp686B22225
Anti-DKFZp434P0721
Anti-5′-3′ exoribonuclease 1
Anti-DKFZp686F19113
Anti-FLJ41903
半岛bd体育手机客户端 介绍:

半岛bd体育手机客户端 说明

一般描述

5→3′ exoribonuclease 1 (XRN1) is a cytoplasmic enzyme, encoded by the gene mapped to human chromosome 3q23. The encoded protein has a molecular mass of 175kDa and is a member of XRN family of exoribonucleases. It is mainly localized in cytoplasmic P- bodies.

应用

Anti-XRN1 antibody produced in rabbit has been used in:

  • immunostaining
  • immunoblotting
  • immunofluorescence.

生化/生理作用

5→3′ exoribonuclease 1 (XRN1) catalyzes the degradation of decapped (5′ monophosphorylated) RNA in the 5′→3′ direction. In addition, it also degrades tRNA (iMet) that is distributed in the cytoplasm. XRN1 is implicated in the modulation of dsRNA accumulation and dsRNA-responsive innate immune effectors. The encoded protein also plays an essential role in maintaining the fidelity of cellular RNA turnover in eukaryotes. XRN1 is required for proper bone formation in humans. Therefore, mutation in the gene leads to development of osteosarcoma.

外形

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

NACRES NA.41

半岛bd体育手机客户端 性质

生物来源 rabbit
偶联物 unconjugated
抗体形式 affinity isolated antibody
antibody product type primary antibodies
克隆 polyclonal
形式 buffered aqueous solution
分子量 antigen ~195 kDa
species reactivity mouse, human
浓度 ~1.0 mg/mL
technique(s) indirect immunofluorescence: 2-5 μg/mL using paraformaldehyde fixed NIH-3T3 cells
western blot: 2-4 μg/mL using nuclear extract of HEK-293T
UniProt登记号 Q8IZH2
运输 dry ice
储存温度 ?20℃
Gene Information human ... XRN1(54464)
mouse ... Xrn1(24127)
rat ... Xrn1(300944)

安全信息

储存分类代码 12 - Non Combustible Liquids
闪点(F) Not applicable
闪点(C) Not applicable

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